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Appropriate monitoring and advice are required for patients with a history of hypertension and/or mild to moderate congestive heart failure as fluid retention and oedema have been reported in association with NSAID therapy.

FertilityBased on the mechanism of actionthe use of NSAIDsincluding Feldenemay delay or prevent rupture of ovarian follicleswhich has been associated with reversible infertility in some womenIn women who have difficulties conceiving or who are undergoing investigation of infertilitywithdrawal of NSAIDsincluding Feldeneshould be considered.

Based on the mechanism of actionthe use of prostaglandin-mediated NSAIDsincluding FELDENEmay delay or prevent rupture of ovarian follicleswhich has been associated with reversible infertility in some womenPublished animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin-mediated follicular rupture required for ovulationSmall studies in women treated with NSAIDs have also shown a reversible delay in ovulationConsider withdrawal of NSAIDsincluding FELDENEin women who have difficulties conceiving or who are undergoing investigation of infertility.

Urogenital SystemAbnormal renal functionc ystitisdysuriahematuriahyperkalemiainterstitial nephritisnephrotic syndromeoliguria/polyuriaproteinuriarenal failureglomerulonephritis.

Hypersensitivity to the active substance or the excipientsprevious skin reactionregardless of severityto piroxicamother NSAIDs and other medications.

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